CURRENT RESEARCH FUNDING: PRINCIPAL
INVESTIGATOR
R01
AI-57661, NIAID,
Molecular Determinants of
Cross-Reactive Antibody Response to Influenza in Humans
PI: James E. Crowe, Jr.
08/15/2012 – 07/31/2016
The purpose of this grant is to isolate
human monoclonal antibodies to influenza, and to study influenza specific human
B cell repertoires, with emphasis on broadly cross-reactive antibodies.
Defense
Threat Reduction Agency (Department of Defense)
Award
Number: HDTRA1-13-1-0034
"Human
monoclonal antibodies against Ebola and Marburg viruses"
Role:
PI
04/01/2013- 03/31/2018
The
purpose of this award is to isolate and study human monoclonal antibodies to filoviruses.
HHSN272200900047C Contract, NIAID/NIH
"Genetic
and structural basis for virus neutralization"
B Cell Epitope Discovery and Mechanisms of Antibody
Protection
Role: PI
09/30/2009
-09/29/2014
This is a B cell epitope
mapping contract focused on H5 influenza and poxvirus epitopes
HHSN272200900055C Contract, NIAID/NIH (PI: Doranz;
Integral Molecular)
Role: Vanderbilt PI of
subcontract
Subcontract to develop human
monoclonal antibodies to hepatitis C and Chikungunya
viruses
07/01/2012-06/30/2013
NIAID, NIH ARRA administrative
award for supplemental funding
"Alphavirus-based Vaccine for Prevention of MPV
Infection"
Role: PI
7/26/10 - 7/25/2012
The purpose of this supplement to
our Regional Centers of Excellence award is to support the production of
experimental vaccine lots for RSV and MPV with testing for immunogenicity and
protective efficacy in nonhuman primates.
Defense Threat Reduction Agency
(Department of Defense)
Award Number: HDTRA1-10-1-0067
"Molecular and structural basis
for fine specificity of antiviral antibodies"
Role: PI
04/01/2013-
03/31/2018
The
purpose of this award is to isolate and characterize human monoclonal
antibodies to Ebola and Marburg viruses form survivors of those infections.
March of
Dimes Foundation
"Epithelial
cell stress response and RSV infection"
Role: PI
2010-2013
The
purpose of this grant is to study the role of stress granule formation in RSV
replication in epithelial cells.
5T32 AI 89554, NIAID, NIH
"Virology Training Program"
Role: PI of the Training Program, and Faculty Mentor
05/01/2010-04/30/2015
This is a training grant program to train PhD
candidate students in molecular and cellular virology research.
CURRENT RESEARCH FUNDING: CO-INVESTIGATOR
R01 AI 059694, NIAID, NIH
Bioinformatics Strategies: Biodefense
Vaccine Research
PI: Jason Moore,
Dartmouth
My role: Consultant
2009-2014
N01 AI 25462, Vaccine Treatment and Evaluation
Unit, NIAID, NIH
Evaluation of control measures against
infectious diseases other than AIDS
Co-Investigator; (PI is Kathryn Edwards)
11/01/2007 – 10/31/2014
This is a vaccine testing center contract. The
bulk of the work in the contract currently is aimed at testing vaccines in
adults for purposes of biodefense. My role is to supervise and conduct
immunology studies, especially concerning H3N2v influenza immunity.
P30 AI-54999, NIAID/ N
U54
AI 057157, NIAID,
NIH
Region
IV Southeast Regional Center of Excellence in Emerging Infections and
Biodefense
Co-Investigator;
(PI is Fred Sparling [UNC-CH])
09/04/09 – 2/28/14
This
award is a multi-institutional award to support regional expertise in
biodefense. I am the project director for Project 9.1, "Genetic and Structural
Determinants of Human Antibodies to Dengue Virus."
P01 AI 078064, NIAID, NIH
Programming HIV Immunity for Broadly Neutralizing
Antibodies by Vaccination
Co-Investigator;
(PI is Nancy Haigwood [Oregon Primate Center]; VUMC
PI is Spyros Kalams)
2/1/09 –
1/31/14
The overall goal is to design novel vaccines based
on Env genes derived from virions
(plasma RNA, not cellular DNA) from HIV-infected subjects who develop broad
Nabs in an accelerated fashion (<3 years). Our part of the project is to
make human mAbs from HIV-infected individuals.
R01 AI 090656 NIAID, NIH (HITIT award)
Broadly Reactive Antibodies against Chimeric
Virus-Host Antigens
PI: Donald Forthal,
UC-Irvine
07/01/2010 - 06/30/2014
Role: Co-Investigator.
The purpose of this grant is to determine whether
humans infected with HIV make antibody responses to antigens that are chimeras
of virus and host proteins.
R01 GM 094198, NIGMS, NIH
Single RNA Sensitive Probes for Studying Viral
Replication and Budding
PI: Philip Santangelo,
Georgia Tech
Role: Co-investigator
7/1/2010-6/30/2015
The purpose of this grant is to develop novel
imaging probes for RNA virus genomes in live cells.
5P30 DK058404-11, NIH/NIDDK (Peek)
Molecular and Cellular Basis of Digestive Disease
06/1/2012 - 05/31/2017
Role: Core Director
This is our Digestive Diseases Research Center. My
role is to direct the flow cytometry shared resource.
5P30 CA068485-15, NIH/NCI
(Pietenpol)
Cancer Center Support
Grant
09/01/2010-08/31/2015
This is a Cancer Center
Support Grant from NCI that supports the Vanderbilt Ingram Cancer Center. I am
Director of the Flow Cytometry Shared Resource.
R21 AI092268, NIAID/NIH
Epitope shifting and antibody
maturation during rotavirus infection
PI: Ben Spiller,
My role: Co-investigator
R21
AI098592, NIAID/NIH (Spearman/Emory)
HIV-specific
B cell repertoire in humans following cross-clade immunization
07/01/2012-06/30/2014
Role:
Co-Investigator